Neurturin (NTN) is a member of the GDNF family of neurotrophic factors.
This protein is a potent survival factor for several populations of central and peripheral neurons in mature and developing rodents.
Supports the survival of sympathetic neurons in culture.
May regulate the development and maintenance of the CNS.
Might control the size of non-neuronal cell population such as haemopoietic cells.
SUBUNIT: Homodimer; disulfide-linked.
DISEASE: Defects in NRTN are a cause of Hirschsprung disease (HSCR).
In association with mutations of RET gene, and possibly with other loci, defects in NRTN are involved in Hirschsprung disease.
This genetic disorder of neural crest development is characterized by the absence of intramural ganglion cells in the hindgut, often resulting in intestinal obstruction.
SIMILARITY: Belongs to the TGF-beta family.
GDNF subfamily.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:2000Optimal dilutions to be determined by the researcher.
Storage and Stability:Lyophilized powder may be stored at -20°C.
Stable for 12 months after receipt at -20°C.
Reconstitute with sterile ddH2O.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Reconstituted product is stable for 12 months at -20°C.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Further dilutions can be made in assay buffer.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Serum
Purity：Serum
Form：Supplied as a lyophilized powder. Reconstitute with 100ul sterile ddH2O.
Specificity：Recognizes human rh NTN. Species Crossreactivity: Mouse, rat
Isotype：IgG
Calc Applications Abbrev：IHC
Calc Crossreactivity：Hu Mo Rt
Immunogen：Recombinant protein corresponding to human Neurturin. Cellular Localization: Secreted protein.
