GDNF is a glycosylated, disulfide-bonded homodimer molecule.
It was first discovered as a potent survival factor for midbrain dopaminergic neurons and was then shown to rescue these neurons in animal models of Parkinson's disease.
GDNF is about 100 times more efficient survival factor for spinal motor neurons than the neurotrophins.
Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake.
SUBUNIT: Homodimer; disulfide-linked.
ALTERNATIVE PRODUCTS: 2 named isoforms produced by alternative splicing.
DISEASE: Defects in GDNF may be a cause of Hirschsprung disease (HSCR).
In association with mutations of RET gene, defects in GDNF may be involved in Hirschsprung disease.
This genetic disorder of neural crest development is characterized by the absence of intramural ganglion cells in the hindgut, often resulting in intestinal obstruction.
DISEASE: Defects in GDNF are a cause of congenital central hypoventilation syndrome (CCHS); also known as congenital failure of autonomic control or Ondine curse.
CCHS is a rare disorder characterized by abnormal control of respiration in the absence of neuromuscular or lung disease, or an identifiable brain stem lesion.
A deficiency in autonomic control of respiration results in inadequate or negligible ventilatory and arousal responses to hypercapnia and hypoxemia.
SIMILARITY: Belongs to the TGF-beta family.
GDNF subfamily.
Applications:Suitable for use in ELISA, Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:500Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：500ul
Host：chicken
Source Antibody：human
Grade：Purified
Purity：Purified
Form：Supplied as a liquid in PBS, 0.02% sodium azide.
Specificity：Recognizes human GDNF. Species Crossreactivity: Mouse, rat
Isotype：IgY
Calc Applications Abbrev：E IHC WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Mixture of two human GDNF peptides aa101-118 and aa199-211. Both peptides are highly conserved in human and mouse. Cellular Localization: Secreted protein.
