A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexins, through which materials of low molecular weight diffuse from one cell to a neighbouring cell.
Each connexin is composed of a hexamer of connexin proteins.
Connexins are a multi-gene family of highly related proteins.
A dozen distinct connexin genes have been identified and many are expressed in a tissue-specific manner.
Two distinct lineages, class I (beta) and class II (alpha), have been identified in mammals.
Connexin-26 belongs to the class 1 (beta) group of connexins.
Mutations in Connexin-26 are associated with genetically derived hearing impairments, including autosomal recessive non syndromic deafness.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1-2ug/mlOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：rabbit
Source Antibody：rat
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.9mg sodium chloride, 0.2mg Na2HPO4, 50% glycerol.
Specificity：Recognizes rat Connexin-26. Species Crossreactivity: Human, mouse, rabbit. Predicted length of 226 residues and MW of 26kD.
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rb Rt
Immunogen：Synthetic peptide corresponding to aa211-226, CYLFIRYCSGKSKRPV, from rat Connexin-26.
