CNTF is a survival promoting factor for different types of neurons in vitro and in vivo.
The essential structural features for the biological function of human CNTF were investigated by Thier, M.
et al.
They showed that deletion of 14 N-terminal and 18 C-terminal amino acids significantly increased bioactivity compared to wild-type CNTF.
CNTF is a survival factor for various neuronal cell types.
Seems to prevent the degeneration of motor axons after axotomy.
SUBUNIT: Homodimer.
CNTF is being tested under the name Axokine by Regeneron Pharmaceuticals for treatment of human motor neuron diseases, such as amyotrophic lateral sclerosis (ALS).
As it induces substantial weight loss, preferentially of fat as opposed to lean body mass, it is being used for obesity treatment.
Belongs to the CNTF family.
Applications:Suitable for use in ELISA, Western Blot and Immunohistochemistry.
Other applications not tested.
Recommended Dilutions:ELISA: 1:500-1:2000Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:500Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：500ul
Host：chicken
Source Antibody：human
Grade：Purified
Purity：Purified
Form：Supplied as a liquid in PBS, 0.02% sodium azide.
Specificity：Recognizes human CNTF. Tissue Specificity: Nervous system. Species Crossreactivity: mouse and rat
Isotype：IgY
Calc Applications Abbrev：E IHC WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Mixture of two peptides from human CNTF aa11-25 and aa186-200, PHRRDLCSRSIWLAR and IPARGSHYIANNKKM. Both peptides are highly conserved among human and mouse. Cellular Localization: Cytoplasm
