Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor.
Has a critical function in regulating the development of cells destined to form and maintain the skeleton.
It is thought to have an important role in signal transduction, cell proliferation and differentiation.
SUBUNIT: Heterodimer.
Interacts with DSIPI; this interaction inhibits the binding of active AP1 to its target DNA.
Interacts with MAFB.
INDUCTION: C-fos expression increases upon a variety of stimuli, including growth factors, cytokines, neurotransmitters, polypeptide hormones, stress and cell injury.
SIMILARITY: Belongs to the bZIP family.
Fos subfamily.
SIMILARITY: Contains 1 bZIP domain.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1ug/mlOptimal dilutions to be determined by the researcher.
Storage and Stability:Lyophilized powder may be stored at -20°C.
Stable for 12 months after receipt at -20°C.
Reconstitute with sterile ddH2O.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Reconstituted product is stable for 12 months at -20°C.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Further dilutions can be made in assay buffer.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a lyophilized powder in 5mg BSA, 0.9mg sodium chloride, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg sodium azide. Reconstitute with 100ul sterile ddH2O.
Specificity：Recognizes human cFOS. Species Crossreactivity: Rat. Predicted length of 380aa and MW of 41kD.
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Rt
Immunogen：Synthetic peptide corresponding to aa170-187, DQLEDEKSALQTEIANLL, from human cFOS. Species Sequence Homology: Mouse. Cellular Localization: Nucleus.
