C-reactive protein has several roles associated with host defence such as; promoting agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine.
It can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.
COFACTOR: Binds 2 calcium ions per subunit.
C-reactive protein exists as a homopentamer.
There are 2 alternatively spliced isoforms.
C-reactive protein is found in plasma and its concentration increases greatly during acute phase response to tissue injury, infection or other inflammatory stimuli.
It is induced by IL-1 and IL-6.
Applications:Suitable for use in ELISA and Western Blot.
Other applications not tested.
Recommended Dilution:ELISA: 1:2000-1:5000Western Blot: 1:2000-1:5000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：chicken
Source Antibody：rat
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.02% sodium azide.
Specificity：Recognizes rat C-Reactive Protein.
Isotype：IgY
Calc Applications Abbrev：E WB
Calc Crossreactivity：Rt
Immunogen：A peptide from rat C-reactive protein aa108-121.
