BDNF belongs to the neurotrophin family and regulates the survival and differentiation of neurons during development.
The alterations in BDNF expression induced by various kinds of brain insult including stress, ischemia, seizure activity and hypoglycemia, may contribute to some pathologies such as depression, epilepsy, Alzheimer's, and Parkinson's disease.
Microglia release BDNF that may contribute to neuroinflammation and neuropathic pain.
Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it.
Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.
The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability.
SUBUNIT: Monomers and homodimers.
Binds to NTRK2/TRKB.
SIMILARITY: Belongs to the NGF-beta family.
Applications:Suitable for use in ELISA.
Other applications not tested.
Recommended Dilution:ELISA: 1:500-1:2000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：500ul
Host：chicken
Source Antibody：human
Grade：Purified
Purity：Purified
Form：Supplied as a liquid in PBS, 0.02% sodium azide.
Specificity：Recognizes human BDNF. Species Crossreactivity: Mouse
Isotype：IgY
Calc Applications Abbrev：E
Calc Crossreactivity：Hu Mo
Immunogen：Mixture of two human BDNF peptides aa73-87 and aa194-208. Both peptides are highly conserved in human and mouse. Cellular Localization: Secreted protein. POst translation modification: Converted into mature BDNF by plasmin (PLG).
