PTPB1 is a multi-functional, ubiquitously expressed heterogeneous nuclear ribonucleoprotein (hnRNP), implicated in pre-mRNA processing, mRNA metabolism and transport.
PTPB1 contains 4 RRM motifs.
PTBP1 is highly over-expressed in glioma and, along with its brain-specific homologue PTBP2, acts as a regulator of neural precursor cell differentiation (Zhang et al.
2013).
There are 3 described isoforms of PTPB1 derived by alternative splicing, isoforms differ in having insertions between the RRM domains 2 and 3.
PTBP1 antibody is expected to recognize all isoforms of PTPB1.
Applications:Suitable for use in ELISA and Western Blot.
Other applications not tested.
Recommended Dilution:ELISA: 1:8000Western Blot: 1ug/ml, detects a band of ~60-65kD in Jurkat cell lysates
Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：goat
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in TBS, 0.5% BSA, 0.02% sodium azide.
Specificity：Recognizes human PTBP1.
Isotype：IgG
Calc Applications Abbrev：E WB
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to sequence DGIVPDIAVGTKR-C from the N-terminal region of PTBP1. Species sequence homology: bovine, canine, mouse, porcine and rat
