Human Interleukin-23 receptor (IL-23R) is a member of the type I cytokine receptor family and mediator of T-cell, NK cell, and possibly macrophage/myeloid cell, stimulation.
IL-23R acts as the receptor for IL-23, through association with the beta component of IL-12R, and is thought to signal through activation of the JAK-STAT signalling pathway.
Genetic variation in IL23R is associated with inflammatory bowel disease type 17 (IBD17), susceptibility to ulcerative, and susceptibility to the inflammatory dermatosis condition, psoriasis.
It is reported as suitable for use in immunocytochemistry on acetone fixed cells.
Applications:Suitable for use in Western Blot and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500Immunohistochemistry (Paraffin): 1:125Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：goat
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.1% BSA, 0.09% sodium azide.
Specificity：Recognizes an epitope within the N-terminal region of human Interleukin-23 Receptor. Species Crossreactivity: Mouse
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Hu Mo
Immunogen：Synthetic peptide corresponding to aa59-87, CQPRKLHFYKNGIKERFQITRINKTTARL, within the N-terminal region of human IL-23 Receptor.
