Human CD305, otherwise known as LAIR-1 (leukocyte-associated Ig-like receptor-1), a transmembrane protein, expressed by natural killer cells, monocytes, dendritic cells, and T cells, and also by other hematopoeitic cells including B cells, but is not expressed by platelets or erythrocytes.
Although structurally related to other killer cell inhibitory receptors, CD305 does not appear to recognize HLA class I, providing a novel mechanism of HLA class I-independent NK cell regulation.
CD305 has been shown to inhibit proliferation, cellular activation and inflammation, and to induce apoptosis in myeloid leukemia cell lines, and found to be expressed at abnormally low levels in naive B cells from HIV-1 infected patients.
Applications:Suitable for use in ELISA, Western Blot.
Other applications not tested.
Recommended Dilution:ELISA: 1:1000Western Blot: 1.0-3.0ug/mlOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：goat
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in Tris, 0.5% BSA, 0.02% sodium azide.
Specificity：Recognizes human CD305.
Isotype：IgG
Calc Applications Abbrev：E WB
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to C-NDTEDVSQASPSE of human CD305. (NP_002278.1, NP_068352.1).
