84-2262-73　［取扱停止］WNT3A (Wingless-type MMTV Integration Site Family Member 3A, Protein Wnt-3a, WNT3A) 50ul　214175

特徴

• The Wnt family includes several secreted glycoproteins that play important roles in animal development (1).
• There are 19 Wnt genes in the human genome that encode functionally distinct Wnt proteins (2).
• Wnt members bind to the Frizzled family of seven-pass transmembrane proteins and activate several signaling pathways (3).
• The canonical Wnt/beta-catenin pathway also requires a coreceptor from the low-density lipoprotein receptor family (4).
• Aberrant activation of Wnt signaling pathways is involved in several types of cancers (5)
• Wnt3a protein is palmitoylated and can function as a growth factor for hematopoietic stem cells (6).
• Although functionally distinct, Wnt3a shows high homology to Wnt3 (7).
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.