TSC1, also named as KIAA0243 and TSC, is implicated as a tumor suppressor.
It is involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling.
In complex with TSC2, TSC1 inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling.
It seems not to be required for TSC2 GAP activity towards RHEB.
It is involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling.
Defects in TSC1 are the cause of tuberous sclerosis complex (TSC).
Defects in TSC1 may be a cause of focal cortical dysplasia of Taylor balloon cell type (FCDBC).
The antibody is specific to TSC1.
Applications:Suitable for use in Immunofluorescence, Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Immunohistochemistry: 1:50-1:100Immunofluorescence: 1:20-1:50Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by affinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes TSC1. Species Crossreactivity: human, mouse, rat
Isotype：IgG
Calc Applications Abbrev：IF IHC WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to human TSC1.
