84-2256-16　［取扱停止］TNFSF13 (Tumor Necrosis Factor Ligand Superfamily Member 13, APRIL, CD256, TALL2, TRDL-1, UNQ383/PRO715, Ligand) 100ul　213854

特徴

• BAFF, a member of the TNF superfamily of proteins, is a homotrimeric transmembrane protein, which is cleaved to produce a soluble cytokine (1).
• BAFF may also further oligomerize into 60-mer structures (1).
• BAFF is expressed by neutrophils, macrophages, dendritic cells, activated T cells, and epithelial cells (1,2).
• BAFF plays a key role in B cell development, survival, and activation (1,3,4).
• BAFF binds to three distinct receptors, BAFF-R, TACI, and BCMA (1).
• These receptors are differentially expressed during B cell development and among B cell subsets (1,2,4).
• While BAFF-R and BCMA bind to the homotrimeric form of BAFF, TACI only binds to membrane bound or higher order BAFF structures (1).
• The BAFF/ BAFF-R interaction activates both canonical and non-canonical NF-kB pathways, PI3K/Akt, and mTOR (2,4).
• Activation of the noncanonical NF-kB pathway via BAFF-R is negatively regulated by TRAF3 (5).
• Elevated levels of BAFF may exacerbate many autoimmune disorders, making it an attractive therapeutic target (2).
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.