84-2251-41　［取扱停止］STEAP3 (Metalloreductase STEAP3, Tumor Suppressor-activated Pathway Protein 6, STMP3, TSAP6, Dudlin-2) 100ul　213614

特徴

• Caspases modulate apoptosis in various ways.
• Specifically, Caspase-3, a death protease, is instrumental in cleaving cellular proteins, dismantling the cell and forming apoptotic bodies.
• pHyde has a potential role as a tumor suppressor by inducing caspase-3-mediated apoptosis and stimulating p53 expression.
• A dose-dependent increase in caspase-3 activity is observed in transduced pHyde DU145 cells.
• Furthermore, caspase-3 may be necessary for pHyde-mediated apoptosis.
• The pHyde gene may upregulate the apoptosis pathway and thus have a potential application in cancer gene therapy.
• Recombinant pHyde inhibits the growth of human prostate cancer cell lines DU145 and LNCaP in vitro.
• DU145 tumors may be reduced significantly in vivo when nude mice are injected with recombinant pHyde.
• pHyde also has a demonstrated growth inhibitory effect on human breast cancer cells.
• This suggests that pHyde may have a role in inhibiting different tumor types.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.