84-2250-28　［取扱停止］SRPX (Sushi Repeat-containing Protein SRPX, DRS, ETX1, SRPX1) 50ul　213566

特徴

• X-linked retinitis pigmentosa (XLRP) is a retinal degeneration disorder.
• The most common form of XLRP has been localized to the gene locus RP3 by linkage and deletion analysis.
• RP3 maps to chromosome Xp21.1 between CYBB and OTC.
• The sushi-repeat-containing protein, x chromosome (SRPX) gene, also designated ETX1, resides within this region and is deleted in XLRP patients.
• There are at least two splice variants of SRPX, one of which contains a thirty amino acid signal peptide.
• Both variants contain three complement control protein domains, a hydrophobic region for membrane anchorage, and a cytoplasmic carboxy terminus.
• SRPX is expressed in retina and heart.
• SRPX is highly homologous to the drs (downregulated by v-src) human homolog, which suggests a role for SRPX as a tumor suppressor.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.