84-2249-21　［取扱停止］SOCS3 (Suppressor of Cytokine Signalling 3, ATOD4, CIS3, Cish3, MGC71791, SOCS-3, SSI-3, SSI3) 200ul　213513

特徴

• The suppressor of cytokine signaling (SOCS) family members are negative regulators of cytokine signal transduction that inhibit the Jak/Stat pathway (1-3).
• The SOCS family consists of at least 8 members including the originally identified cytokine-inducible SH2-containing protein (CIS1), as well as SOCS1-7.
• Each SOCS family member contains a central SH2 domain and a conserved carboxy-terminal motif designated as the SOCS box.
• These proteins are important regulators of cytokine signaling, proliferation, differentiation, and immune responses.
• Low levels of SOCS3 are observed in lung, spleen and thymus, and like other SOCS family members levels its expression is rapidly induced by a number of factors including interleukins, EPO, IFN-gamma, CSF and TNF-alpha (4).
• SOCS3 uses its SH2 domain to bind activated Jaks and their cognate receptors to provide negative feedback inhibition.
• In addition to the initially described inducers of SOCS3 expression, subsequent studies have described SOCS3-mediated negative feedback inhibition for leptin (5), GH (6), chemokine receptors (7), insulin (8) and certain pathogens (9,10).
• SOCS3 deletion results in embryonic lethality with placental insufficiency (11).
• SOCS3 signaling has been linked pathologically to allergic responses (12), inflammatory disease (13), endotoxic shock (14), wound repair (15), and obesity (16,17).
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.