84-2229-33　［取扱停止］PGC (Progastricsin, Pepsinogen C, PEPC, PGII) 200ul　212577

特徴

• This gene encodes an aspartic proteinase that belongs to the peptidase family A1.
• The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa.
• This protein is also secreted into the serum.
• This protein is synthesized as an inactive zymogen that includes a highly basic prosegment.
• This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself.
• Polymorphisms in this gene are associated with susceptibility to gastric cancers.
• Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis.
• Alternate splicing results in multiple transcript variants.
• A pseudogene of this gene is found on chromosome 1.
• Applications:Suitable for use in Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:100Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.