84-2227-01　［取扱停止］PAK4 (p21 Protein Activated Kinase 4) 100ul　212471

特徴

• PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4.
• PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling.
• They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities.
• PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases.
• PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton.
• Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.