84-2215-71　［取扱停止］MDM2, phosphorylated (S166) (Murine Double Minute-2, HDMX, HDM2, ACTFS) 50ul　211955

特徴

• This gene encodes a nuclear-localized E3 ubiquitin ligase.
• The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation.
• This gene is itself transcriptionally-regulated by p53.
• Overexpression or amplification of this locus is detected in a variety of different cancers.
• There is a pseudogene for this gene on chromosome 2.
• Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells.
• Applications:Suitable for use in Immunofluorescence and Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Immunofluorescence: 1:100-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.