84-2215-21　［取扱停止］MC1R (Melanocortin Receptor 1, CMM5, MSH-R, SHEP2) 100ul　211932

特徴

• This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH).
• The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis.
• Two types of melanin exist: red pheomelanin and black eumelanin.
• Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color.
• Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation.
• Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis.
• This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.