84-2210-06　［取扱停止］KRT8, phosphorylated (S74) (Cytokeratin 8, Keratin 8, K8, KO, CK8, CK-8, CYK8, K2C8, CARD2) 200ul　211705

特徴

• This gene is a member of the type II keratin family clustered on the long arm of chromosome 12.
• Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells.
• The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells.
• This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation.
• Mutations in this gene cause cryptogenic cirrhosis.
• Alternatively spliced transcript variants have been found for this gene.
• Applications:Suitable for use in Immunofluorescence, Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Immunofluorescence: 1:100-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.