84-2204-73　［取扱停止］IL13 (Interleukin 13, ALRH, BHR1, IL-13, MGC116786, MGC116788, MGC116789, P600) 50ul　211456

特徴

• IL-13 is produced by T cells and is important in the TH2 response.
• IL-13 targets include B cells, eosinophils, fibroblasts, mast cells and macrophages (1-3).
• IL-13 binds specifically to IL-13Ra1 that complexes with IL-4Ra to form the Type II IL-4R.
• Jak1 and Tyk2 are activated and signal through Stat3 and Stat6 (6).
• IL-13Ra2 is a different gene product, lacks the intracellular domain, does not complex with IL-4Rα and does not signal (1,6,7).
• The extracellular domain of IL-13Ra2 is often elevated in diseased states.
• IL-13 plays key roles in airway hyperresponsiveness (AHR) of allergic asthma (1,4,5) and modulates resistance to parasitic organisms (1).
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.