84-2203-83　［取扱停止］IFNA1 (Interferon-a1, Interferon alpha 1, IFL, IFN, IFN-Alpha, IFNA13, IFNA, MGC138207, MGC138505, MGC138507) 100ul　211419

特徴

• Interferon-a1 is a member of the Type I IFN (1) family best known for their antiviral activity.
• Most nucleated cells produce one or more Type I IFNs in response to viral infection (2).
• Secreted Type I IFN then induces viral protective responses in neighboring non-infected cells.
• Type I IFNs also enhance virus-induced apoptosis (3).
• Other IFNA11 activities include enhancement of dendritic cell maturation and cytotoxic T cell activity (4).
• IFNA11 binds to the IFNA1R1 and IFNA1R2 heterodimer (1).
• Intracellular signaling through the Jak/Stat pathway is best characterized (3).
• However, the PI3K, ERK, and p38 kinase pathways are also involved (5).
• The antiviral activities of the IFNs have led to their use in treating viral infections (4).
• Type I IFNs also appear to have an integral role in several autoimmune diseases (6).
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.