84-2202-69　［取扱停止］HSPA5 (Heat Shock Protein 5, 78kD, BIP, FLJ26106, Glucose Regulated Protein 78, GRP78, MIF2) 200ul　211373

特徴

• Secretory and transmembrane proteins are synthesized on polysomes and translocated into the endoplasmic reticulum (ER).
• Inside the ER, these proteins are often modified by disulfide bond formation, amino-linked glycosylation and folding.
• To help proteins fold properly, the ER contains a pool of molecular chaperones including HSPA5.
• HSPA5 was identified as an immunoglobulin heavy chain binding protein in pre-B cells (1,2).
• It was also found to be induced at the protein level by glucose starvation (3).
• When protein folding is disturbed inside ER, HSPA5 synthesis is increased.
• Subsequently, HSPA5 binds to misfolded proteins to prevent them from forming aggregates and assists in proper refolding (4).
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.