Forkhead box (Fox) proteins are a family of evolutionarily conserved transcription factors containing a sequence known as Forkhead box or winged helix DNA binding domain (1).
The human genome contains 43 Fox proteins that are divided into subfamilies.
The FoxP subfamily has four members, FoxP1 to FoxP4, which are broadly expressed and play important roles in organ development, immune response, and cancer pathogenesis (2-4).
The FoxP subfamily has several characteristics that are atypical among Fox proteins: their Forkhead domain is located at the carboxy-terminal region, and they contain motifs that promote homo- and heterodimerization.
FoxP proteins usually function as transcriptional repressors (4,5)
FoxP3 is crucial for the development of T cells with regulatory properties (Treg) (6).
Mutations in FoxP3 are associated with immunodeficiency polyendocrinopathy, enteropathy, and X-linked syndrome (IPEX) (7), while overexpression in mice causes severe immunodeficiency (8).
In addition, FoxP3 functions as a tumor suppressor in several types of cancer (9-11).
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by affinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes FOXP3. Species Crossreactivity: human, mouse, rat
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Recombinant protein corresponding to human FOXP3.
