84-2190-91　［取扱停止］FKBP4 (FK506 Binding Protein 4, HBI, p52, Hsp56, FKBP51, FKBP52, FKBP59, PPIase) 200ul　210859

特徴

• The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking.
• This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin.
• It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506.
• It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes.
• This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase.
• It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors.
• This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines.
• Thus this encoded protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy.
• The human genome contains several non-transcribed pseudogenes similar to this gene.
• Applications:Suitable for use in Immunofluorescence and Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Immunofluorescence: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.