This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription.
The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2.
Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone.
Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis.
Alternative splicing results in several transcript variants, which differ in their 5' UTRs and use different promoters.
Applications:Suitable for use in Immunofluorescence and Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunofluorescence: 1:100-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by affinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes ESR1, phosphorylated S106. Species Crossreactivity: human, mouse
Isotype：IgG
Calc Applications Abbrev：IF WB
Calc Crossreactivity：Hu Mo
Immunogen：Phospho specific peptide corresponding to residues surrounding S106 of human ESR1.
