84-2183-10　［取扱停止］DNMT3B (DNA-methyltransferase 3B, ICF, ICF1, M.HsaIIIB) 50ul　210519

特徴

• CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation.
• Studies in mice have demonstrated that DNA methylation is required for mammalian development.
• This gene encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation.
• The protein localizes primarily to the nucleus and its expression is developmentally regulated.
• Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome.
• Eight alternatively spliced transcript variants have been described.
• The full length sequences of variants 4 and 5 have not been determined.
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• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:200-1:1000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.