84-2180-89 ［取扱停止］DCX (Doublecortin, Lissencephalin-X, Lis-X, DC, DBCN, LISX, SCLH, XLIS) 100ul 210416
特徴
- Mutations in Doublecortin cause Lissencephaly (smooth brain), a neuronal migration disorder characterized by epilepsy and mental retardation (1).
- Doublecortin is a microtubule associated protein that stabilizes and bundles microtubules.
- A conserved doublecortin domain mediates the interaction with microtubules, and interestingly most missense mutations cluster in this domain (2).
- Kinases JNK, CDK5 and PKA phosphorylate doublecortin.
- JNK phosphorylates Thr321, Thr331 and Ser334 while PKA phosphorylates Ser47 and CDK5 phosphorylates Ser297 (3-5).
- Phosphorylation of Ser297 lowers the affinity of doublecortin to microtubules.
- Furthermore, mutations of Ser297 result in migration defects (5).
- Applications:Suitable for use in Western Blot.
- Other applications not tested.
- Recommended Dilution:Western Blot: 1:500-1:2000Optimal dilutions to be determined by the researcher.
- Storage and Stability:May be stored at 4°C for short-term only.
- Aliquot to avoid repeated freezing and thawing.
- Store at -20°C.
- Aliquots are stable for 12 months after receipt.
- For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
- Size：100ul
- Host：rabbit
- Source Antibody：human
- Grade：Affinity Purified
- Purity：Purified by affinity chromatography.
- Form：Supplied as a liquid in PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
- Specificity：Recognizes DCX. Species Crossreactivity: human, mouse, rat
- Isotype：IgG
- Calc Applications Abbrev：WB
- Calc Crossreactivity：Hu Mo Rt
- Immunogen：Recombinant protein corresponding to human DCX.
- Shelf Life：1year
- Swiss Prot Number：O43602
- EU Commodity Code：30021010
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