The protein encoded by this gene is a gastric aspartyl protease that functions as a disulfide-linked homodimer.
This protease, which is a member of the peptidase C1 family, has a specificity similar to that of pepsin A and cathepsin D.
It is an intracellular proteinase that does not appear to be involved in the digestion of dietary protein and is found in highest concentration in the surface of epithelial mucus-producing cells of the stomach.
It is the first aspartic proteinase expressed in the fetal stomach and is found in more than half of gastric cancers.
It appears, therefore, to be an oncofetal antigen.
Transcript variants utilizing alternative polyadenylation signals and two transcript variants encoding different isoforms exist for this gene.
[provided by RefSeq, Jul 2008]
Applications:Suitable for use in Immunofluorescence and Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunofluorescence: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by affinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes CTSE. Species Crossreactivity: human, mouse, rat
Isotype：IgG
Calc Applications Abbrev：IF WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Recombinant protein corresponding to human CTSE.
