Human c-Reactive protein (CRP) was discovered in serum of patients as a nonantibody precipitin of the C-polysaccharide from pneumococci(1).
During acute infection, the amounts of circulating CPR increases 100-1000 fold (2).
Serum CRP values are routinely measured to detect or monitor many human diseases and minor elevations of C-reactive protein are predictive of cardiovascular events in patients with coronary heart disease (3).
CRP promotes host defense, is an efficient activator of the classical C cascade, and shown to be opsonic (4).The opsonic and C activation activities are responsible for the nonspecific host defense activities providing protection in the preimmune stage of acute infections.
Additionally, IL-1 and IL-6 are known to stimulate CRP biosynthesis (5).
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by affinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes human CRP.
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu
Immunogen：Recombinant protein corresponding to human CRP.
