84-2156-82　［取扱停止］ABCC4 (ATP-binding Cassette Sub-Family C Member 4, EST170205, MOAT-B, MOATB, MRP4) 100ul　209321

特徴

• ABCC4 is a member of the ATP-binding Cassette (ABC) transporter family.
• ABC proteins transport various molecules across cellular membranes by utilizing the energy generated from ATP hydrolysis.
• There are seven subfamilies of ABC proteins: ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White (1).
• ABCC4 belongs to the MRP subfamily, which is involved in multi-drug resistance, hence it is also named MRP4.
• ABCC4 is widely expressed in cells and tissues including prostate, kidney proximal tubules, astrocytes and capillary endothelial cells of the brain, platelets, and many cancer cell lines (2-4).
• ABCC4 mediates efflux transport of a wide variety of endogenous and xenobiotic organic anionic compounds (5).
• The diversity of substrates determines the biological functions of ABCC4.
• It regulates cAMP levels in human leukemia cells, thereby controlling the proliferation and differentiation of leukemia cells (6).
• ABCC4 also enables COX deficient pancreatic cancer cells to obtain exogenous prostagladins (7).
• Researchers have shown that ABCC4 expression is elevated in drug resistant cancer cells, which makes it a potential target for cancer therapy (8,9).
• ABCC4 localizes to both plasma membrane and intracellular membranous structures (10).
• Investigators have also implicated ABCC4 in the pathogenesis of Kawasaki desease, a genetic childhood disease characterized by vasculitis (11).
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.