84-2153-24　UNC5B (aa629-643) (Netrin receptor UNC5B, P53RDL1, p53-regulated receptor for death and life protein 1, Protein unc-5 homolog 2, Protein unc-5 homolog B, Transmembrane receptor Unc5H2, Unc-5 homolog 2, Unc-5 homolog B (C. elegans), UNC5H2) 100ug　208500

特徴

• Receptor for netrin required for axon guidance.
• Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding.
• Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion.
• It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand.
• Mediates apoptosis by activating DAPK1.
• In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity.
• Applications:Suitable for use in Peptide ELISA and Western Blot.
• Other applications not tested.
• Recommended Dilution:Peptide ELISA: 1:64,000Western Blot: 1-3ug/mlOptimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.