Caspases are cysteine proteases that cleave C-terminal aspartic acid residues on their substrate molecules.
This gene is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines.
In rodents, the homolog of this gene mediates apoptosis in response to endoplasmic reticulum stress.
However, in humans this gene contains a polymorphism for the presence or absence of a premature stop codon.
The majority of human individuals have the premature stop codon and produce a truncated non-functional protein.
The read-through codon occurs primarily in individuals of African descent and carriers have endotoxin hypo-responsiveness and an increased susceptibility to severe sepsis.
Several alternatively spliced transcript variants have been noted for this gene.
Applications:Suitable for use in Peptide ELISA and Western Blot.
Other applications not tested.
Recommended Dilution:Peptide ELISA: 1:128,000Western Blot: 0.3-1ug/mlOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：goat
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in Tris saline, pH 7.3, 0.5% BSA, 0.02% sodium azide.
Specificity：Recognizes human Caspase 12.
Isotype：IgG
Calc Applications Abbrev：E WB
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to aa232-244 from sequence C-TDSGKAGADTHGR, at the internal region of the protein sequence according to NP_001177945.1.
