The protein encoded by this gene contains an ATS1/RCC1-like domain, a RhoGEF domain, and a vacuolar protein sorting 9 (VPS9) domain, all of which are guanine-nucleotide exchange factors that activate members of the Ras superfamily of GTPases.
The protein functions as a guanine nucleotide exchange factor for the small GTPase RAB5.
The protein localizes with RAB5 on early endosomal compartments, and functions as a modulator for endosomal dynamics.
Mutations in this gene result in several forms of juvenile lateral sclerosis and infantile-onset ascending spastic paralysis.
Multiple transcript variants encoding different isoforms have been found for this gene.
Applications:Suitable for use in Peptide ELISA, Western Blot and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Peptide ELISA: 1:8000Western Blot: 1ug/mlImmunohistochemistry: 3-5ug/mlOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：goat
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in Tris saline, pH 7.3, 0.5% BSA, 0.02% sodium azide.
Specificity：Recognizes human ALS2.
Isotype：IgG
Calc Applications Abbrev：E IHC WB
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to LKACYYQIQREKLN of human ALS2 at C-terminal. Species sequence homology: mouse, rat, canine and bovine
