84-2147-61　［取扱停止］Receptor for Advanced Glycosylation End (RAGE) 200ul　171746

特徴

• RAGE is a member of the immunoglobulin superfamily of cell surface molecules that binds molecules that have been irreversibly modified by non-enzymatic glycation and oxidation, and are know as advanced glycation end products (AGEs).
• It is expressed by endothelium, mononuclear phagocytes, neurons and smooth muscle cells.
• Whereas RAGE is present at high levels during development, especially in the central nervous system, its levels decline during maturity.
• The increased expression of RAGE is associated with several pathological states, such as diabetic vasculopathy, neuropathy, retinopathy and other disorders, including Alzheimer's disease and immune/inflammatory reactions of the vessel walls.
• In diabetic tissues, the production of RAGE is due to the overproduction of AGEs that eventually overwhelm the protective properties of RAGE.
• This results in oxidative stress and endothelial cell dysfunction that leads to vascular disease in diabetics.
• In the brain, RAGE also binds amyloid beta (A beta).
• Because A beta is overproduced in neurons and vessels in the brains of Alzheimer disease, this leads to the hyperstimulation of RAGE.
• The RAGE-A beta interaction is thought to result in oxidative stress leading to neuronal degeneration.
• Applications:Suitable for use in ELISA and Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:ELISA: 1:260,676Immunohistochemistry (Paraffin): 1:400Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.