Although the function of k-opioid receptors is unclear, recent evidence indicates that activation of the k-opioid receptor opposes a variety of mu-opioid receptor mediated actions throughout the brain and spinal cord.
In general, opioids modulate numerous central and peripheral processes, including pain perception, neuroendocrine secretion and the immune response.
The opioid signal is transduced from receptors through G proteins to various different effectors.
Subsequent to G protein activation, several effectors are known to orchestrate the opioid signal.
For example, activation of opioid receptors increases phosphatidylinositol turnover, activates K+ channels and reduces adenylyl cyclase and Ca++ channel activities.
Applications:Suitable for use in ELISA, Western Blot, Immunohistochemistry and ABC.
Other applications not tested.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Storage and Stability:Lyophilized and reconstituted products are stable for 12 months after receipt at -20°C.
Reconstitute with sterile PBS, 10mg/ml BSA.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Further dilutions can be made in assay buffer.
仕様
Size：100ul
Host：rabbit
Source Antibody：rat
Grade：Serum
Purity：Serum
Form：Supplied as a lyophilized powder. Reconstitute with 100ul sterile PBS, 10mg/ml BSA.
Specificity：Recognizes rat Opioid, Kappa Receptor. Species Crossreactivity: Rat Kappa Opioid Receptor 70%. No Species Crossreactivity: Delta Opioid Receptor (360-372), Delta Opioid Receptor, Mu Opioid Receptor (391-398), Mu Opioid Receptor.
Isotype：IgG
Calc Applications Abbrev：E IHC WB
Calc Crossreactivity：Rt
Immunogen：Peptide corresponding to aa346-380 from Rat Opioid Receptor, Kappa at C-terminal.
