WNK1, a WNK type protein kinase, contains a small N-terminal domain followed by a kinase domain and a long C-terminal tail.
The protein is cytoplasmic and has been shown to regulate both the c-Jun N-terminal kinase pathway and the actin cytoskeleton in vitro.
WNK1 has been identified as the gene mutant in pseudohypoaldosteronism type 2, also known as Gordon hyperkalemia-hypertension syndrome, which is a rare autosomal dominant form of volume-dependent, low-renin hypertension.
Disease-causing mutations are large intronic deletions that increase WNK1 expression.
At least two variants of WNK1 are produced by alternative splicing.
Applications:Suitable for use in Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Immunohistochemistry (Formalin fixed paraffin embedded): 5-7.5ug/mlOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.09% sodium azide.
Specificity：Recognizes human WNK1. Species Crossreactivity (tested or 100% immunogen sequence identity): bat, equine, hamster, monkey, mouse, rabbit and rat.
Isotype：IgG
Calc Applications Abbrev：IHC
Calc Crossreactivity：Eq Hm Hu Mk Mo Rb Rt
Immunogen：Synthetic peptide corresponding to 17aa from the C-terminus of human WNK1. Species Sequence Homology: bat, elephant, gibbon, gorilla, hamster, equine, marmoset, monkey, mouse, opossum, panda, rabbit, rat (100%); porcine (94%); bovine (88%).
