TAOK1 enhances microtubule dynamics through the activation of MARK (microtubule affinity regulating kinase) that leads to phosphorylation and detachment of tau and other MAPs from microtubules causing destabilization.
TAOK1 also interacts via downstream targets such as JNK and ROCK-1 to regulate apoptotic morphology associated with the execution phase of apoptosis, which involves reorganization of the actin cytoskeleton.
Applications:Suitable for use in Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Immunohistochemistry (Formalin fixed paraffin embedded): 5ug/mlOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.09% sodium azide.
Specificity：Recognizes human TAOK1. Species Crossreactivity: gibbon, gorilla and monkey.
Isotype：IgG
Calc Applications Abbrev：IHC
Calc Crossreactivity：Hu Mk
Immunogen：Synthetic peptide corresponding to 15aa from the internal region of human TAOK1. Species sequence homology: bat, bovine, chicken, canine, xenopus, hamster, equine, mouse, porcine, rabbit and rat.
