Somatostatin negatively regulates the growth of various normal and tumor cells via five somatostatin receptors.
Somatostatin receptors are expressed by a large variety of human tumors, and the predominant expression of SST2 receptors in tumor tissues forms the basis for the successful application of SST2-preferring agonists in the treatment of patients with GH-secreting pituitary adenomas, as well as in patients with carcinoid or islet cell tumors.
The SST2 receptor exists as two splice variants that differ in length and composition of their intracellular carboxy termini.
SST2 is the only member of the somatostatin receptor family that contains introns.
Applications:Suitable for use in Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Immunohistochemistry (Formalin fixed paraffin embedded): 10ug/mlOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.09% sodium azide.
Specificity：Recognizes human SSTR2. Species Crossreactivity: bovine, canine, chicken, guinea pig, equine, hamster, monkey, mouse, porcine, rabbit, rat, gibbon, bat
Isotype：IgG
Calc Applications Abbrev：IHC
Calc Crossreactivity：Bo Ca Ch Eq Gp Hm Hu Mk Mo Po Rb Rt
Immunogen：Synthetic peptide corresponding to 18aa from 3rd cytoplasmic domain of human SSTR2. Species sequence homology: xenopus.
