Scn9a encodes the alpha subunit of the type IX voltage-gated sodium channel.
These channels, composed of one alpha and one or two beta subunits, mediate changes in cell permeability to sodium ions that are essential for the generation of action potentials.
The alpha subunit alone can generate a functional channel in vitro >, but it's kinetic properties are modulated by beta subunits.
The type IX channel is tetrodotoxin sensitive and is believed to function in hyperexcitability induced pain.
At least two mRNA variants have been reported.
Scn9a protein has been observed to accumulate abnormally in human neuromas.
Applications:Suitable for use in Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Immunohistochemistry (Formalin fixed paraffin embedded): 10ug/mlOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.09% sodium azide.
Specificity：Recognizes human SCN9A/Nav1.7. Species Crossreactivity: gorilla and gibbon.
Isotype：IgG
Calc Applications Abbrev：IHC
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to 17aa from the internal region of human SCN9A/Nav1.7. Species sequence homology: bovine, canine, equine, monkey, mouse, porcine and rabbit.
