Scn1a encodes the alpha subunit of the type I voltage-gated sodium channel.
These channels, composed of one alpha and one or two beta subunits, mediate changes in cell permeability to sodium ions that are essential for the generation of action potentials.
The alpha subunit alone has been shown to generate a functional channel in vitro, but it's kinetic properties are modulated by beta subunits.
The type I channel is tetrodotoxin sensitive.
At least two mRNA variants have been reported.
Mutations in SCN1A are associated with severe myoclonic epilepsy in infancy (SMEI) and 'generalized epilepsy with febrile seizures plus' type two (GEFS+2).
Applications:Suitable for use in Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Immunohistochemistry (Formalin fixed paraffin embedded): 5ug/mlOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.09% sodium azide.
Specificity：Recognizes human SCN1A/Nav1.1. Species Crossreactivity: gorilla, gibbon, monkey, mouse, rat, bat, canine, hamster, equine, porcine, rabbit, chicken, xenopus
Isotype：IgG
Calc Applications Abbrev：IHC
Calc Crossreactivity：Ca Ch Eq Hm Hu Mk Mo Po Rb Rt Xe
Immunogen：Synthetic peptide corresponding to 16aa from the N-terminus of human SCN1A/Nav1.1. Species sequence homology: bovine and zebrafish.
