PTP alpha, a R4 receptor protein tyrosine phosphatase, is implicated in neuron formation, retinal development, cell adhesion, potassium channel regulation, nerve repair, insulin signaling, and cell cycle regulation.
PTP alpha activates the Src protein tyrosine kinase during mitosis, resulting in the transition from G2 to mitosis in the cell cycle.
PTP alpha is associated with carcinomas of breast, colon, oral squamous cell and prostate.
A cytosolic form of PTP alpha, p66 PTP alpha, has recently been isolated.
p66 PTP alpha is produced by calpain-mediated proteolytic cleavage and its expression has been detected in nearly all cell types where PTP alpha is expressed.
Applications:Suitable for use in Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Immunohistochemistry (Formalin fixed paraffin embedded): 15ug/mlOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.09% sodium azide.
Specificity：Recognizes human PTPRA. Species Crossreactivity: gorilla and gibbon.
Isotype：IgG
Calc Applications Abbrev：IHC
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to 17aa from the extracellular domain of human PTPRA. Species sequence homology: rat and monkey.
