Nak1, a NR4 Nerve Growth Factor-Like receptor, has been shown to affect the hypothalamic-pituitary axis, neuronal differentiation, neuroendocrine regulation of adrenocortical function, and T-cell apoptosis.
Nak1 also is known as nuclear receptor Tr3 and is similar to mouse Nur77 and rat NGFI-B.
It is encoded by one of the immediate early genes (IEG) in response to nerve growth factor and other serum growth factors.
Nak1 can bind to DNA as a monomer, homodimer, or heterodimer (with retinoid X receptors).
Nak1 has been shown to inhibit vascular lesion formation and could serve as a novel target in the treatment of vascular diseases.
Applications:Suitable for use in Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Immunohistochemistry (Formalin fixed paraffin embedded): 16ug/mlOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.09% sodium azide.
Specificity：Recognizes human NR4A1/NUR77. Species Crossreactivity: gorilla, orangutan, gibbon, monkey, mouse, rat, hamster
Isotype：IgG
Calc Applications Abbrev：IHC
Calc Crossreactivity：Hm Hu Mk Mo Rt
Immunogen：Synthetic peptide corresponding to 15aa from N-terminus of human NR4A1/NUR77. Species sequence homology: bovine, canine, equine and monkey.
