Rev-erbA alpha, a NR1 Thyroid Hormone-Like Receptor, is encoded by the same genomic locus as, but transcribed from the opposite strand of, Thyroid Hormone Receptor Alpha (TR Alpha).
Rev-erbA alpha is a target of Nuclear Receptor ROR Alpha (Delerive et al.
2002), and a transcription regulator that has been shown to affect myocyte differentiation, adipogenesis, and lipoprotein metabolism.
Recently Reb-erbA alpha has been shown to affect circadian rhythms by regulating cyclic Bmal1 transcription ( Preitner et al.
2002, Ueda et al.
2002).
Mice lacking Rev-erbA alpha show abnormal postnatal cerebellar development.
Applications:Suitable for use in Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Immunohistochemistry (Formalin fixed paraffin embedded): 1ug/mlOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.09% sodium azide.
Specificity：Recognizes human NR1D1. Species Crossreactivity: canine, rabbit
Isotype：IgG
Calc Applications Abbrev：IHC
Calc Crossreactivity：Ca Hu Rb
Immunogen：Synthetic peptide corresponding to 15aa from the internal region of human NR1D1. Species sequence homology: bat, gibbon, gorilla, equine, monkey and porcine.
