Maxi-K channels, also known as BK channels, consist of a pore-forming alpha subunit and a regulatory beta subunit, which confers the channel with a higher calcium sensitivity.
Homologs of the Drosophila melanogaster calcium-activated potassium channel gene, slowpoke, the mouse and human genes generate multiple transcripts by alternative splicing.
The splice variants differ significantly in their Ca2+ sensitivity, suggesting a broad functional role for these channels in the regulation of neuronal excitability.
The alpha-subunit shows a tissue distribution different to that of the beta-subunit, and in many tissues there may be no association of alpha-subunits with beta-subunits.
The beta-subunits can play a functional role in the regulation of neuronal excitability by tuning the Ca2+ and/or the voltage dependence of alpha-subunits (Tseng-Crank et al., 1996).
Maxi-K channels may have potential utility of gene therapy for urinary incontinence and erectile dysfunction.
Applications:Suitable for use in Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Immunohistochemistry (Formalin fixed paraffin embedded): 2.5ug/mlOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.09% sodium azide.
Specificity：Recognizes human KCNE3. Species Crossreactivity: monkey, mouse, rat, bovine, canine, hamster, porcine, rabbit, chicken, xenopus, zebrafish
Isotype：IgG
Calc Applications Abbrev：IHC
Calc Crossreactivity：Bo Ca Ch Hm Hu Mk Mo Po Rb Rt Xe Ze
Immunogen：Synthetic peptide corresponding to 15aa from the internal region of human KCNMA1.
