84-2142-53　GPR37 (EDNRBL, ETBR-LP-1, Gpcr/cns1, HET(B)R-LP, Het-b-r-lp, PAELR, Pael Receptor) 50ug　170715

特徴

• GPR37 is an Orphan-A GPCR with an unknown ligand.
• GPR37 was recently identified as the PAEL receptor, a Parkin substrate involved in autosomal recessive juvenile Parkinson's (PDJ) disease.
• The PAEL receptor becomes unfolded, insoluble, and ubiquitinated when overexpressed, leading to unfolded protein-induced cell death.
• When the PAEL receptor is ubiquitinated by Parkin, it gets degraded, resulting in the suppression of cell death.
• Applications:Suitable for use in Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Immunohistochemistry (Formalin fixed paraffin embedded): 6-11ug/mlOptimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.