GalR1 is a Galanin Receptor that mediates the effects of the peptide galanin in a wide variety of tissues.
Unlike GalR2, the primary signaling mechanism of GalR1 is by inhibiting adenylate cyclase through Gi.
GalR1 regulates the GnRH neuroendocrine axis with its expression in POMC neurons.
Pathogens like E.
coli can cause diarrhea by increasing expression of Galanin Receptor 1 in the epithelial cells lining the colon, resulting in increased secretion of colonocyte chloride and fluid.
Applications:Suitable for use in Immunohistochemistry.
Not suitable for Immunocytochemistry, Immunofluorescence, Western Blot, Immunoprecipitation or Flow Cytometry.
Other applications not tested.
Recommended Dilution:Immunohistochemistry (Formalin fixed paraffin embedded): 100ug/mlOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.09% sodium azide.
Specificity：Recognizes human GALR1. Species crossreactivity: gibbon, gorilla and monkey.
Isotype：IgG
Calc Applications Abbrev：IHC
Calc Crossreactivity：Hu Mk
Immunogen：Synthetic peptide corresponding to 19aa from 2nd extracellular domain of human GALR1.
