FZD2 is a Frizzled Receptor that mediates Wnt signaling, which is required for proper axis development in the embryo.
FZD2 is developmentally regulated.
Studies of rat FZD2 indicate that the protein signals through a calcium-releasing pathway and that FDZ2 expression modulates protein kinase C (PKC) localization and stimulates PKC activity in vitro.
Increased levels of FZD2 mRNA have been observed in primary gastric cancer and in head and neck squamous carcinoma and gastric cancer cell lines.
Applications:Suitable for use in Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Immunohistochemistry (Formalin fixed paraffin embedded): 8ug/mlOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.09% sodium azide.
Specificity：Recognizes human FSD2/Frizzled 2. Species Crossreactivity: bovine, canine, hamster, equine, monkey, gorilla, mouse, porcine, rabbit, rat
Isotype：IgG
Calc Applications Abbrev：IHC
Calc Crossreactivity：Bo Ca Eq Hm Hu Mk Mo Po Rb Rt
Immunogen：Synthetic peptide corresponding to 20aa from the N-terminus of human FSD2/Frizzled 2.
