Formyl peptide receptor 1, a Chemoattractant Receptor, mediates chemotaxis, degranulation, and superoxide production, as part of the inflammatory response.
Bacterial N-formylmethionyl peptides and Annexin A1, specific ligands for FPR1, attract polymorphonuclear neutrophils to sites of infection.
FPR receptors promote the phosphorylation and downregulation of CCR5, which has been shown to inhibit HIV infection.
Therefore, ligands for an FPR receptor may be able to inhibit HIV infection.
Applications:Suitable for use in Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Immunohistochemistry (Formalin fixed paraffin embedded): 2ug/mlOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.09% sodium azide.
Specificity：Recognizes human FPR1.
Isotype：IgG
Calc Applications Abbrev：IHC
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to 16aa from 2nd extracellular domain of human FPR1. Species sequence homology: chimpanzee and gorilla.
